Photo: NCI, Unsplash
Repairing Aging Muscle Damage With Young Blood Vampire Solution:
We’ve written here before about many new ideas on how to live longer.
From time to time, the scope of those ideas can range wildly.
Whether it’s the crazy Russian immortality 2045 guys, or people as reputable as Salk Institute researchers.
Scientists are starting to look at Aging as a treatable disease.
-To say nothing of the maximization-potential like a type of “steroids for everything” and upgrading to “better-than-stock”, that we might discover after we fix the aging problems.
As some really wacky ancient beliefs would have it,
A lot of that research actually centers around the difference between young and old blood. UPMC’s researchers just found another big piece of that puzzle…
The Short Answer:
- We all want to live longer.
- Some theorists out there have some pretty crazy solutions.
- Others are pursuing more sensible paths that see Aging as a treatable disease.
- Along that path, hopefully there will be innovations for repairing our bodies, too.
- A fair bit of this research deals with many successful anti-aging trials using the blood of younger individuals.
- So far, one of the helpful compounds these trials have found is called GDF11.
- Those trials also acknowledged it won’t be the only one.
- Some of the trials involving blood-exchange resulted in better joint cartilage, exercise ability, and overall brainpower.
- Another problem older people face is that their muscles don’t repair well; instead they scar.
- Fabrisia Ambrosio’s team at UPMC found the solution to this.
- Older people have a less-functional messaging-system in their blood, and too little of the repair signal gets to the right place.
- This looks like it might be fixed by injecting them with more of the missing “envelopes” that travel through the blood.
- Similar to the previous experiments, the team used plasma from young mice to find & fix the problem.
- This simple restocking of “envelopes” might be a big step in treating the disease of aging, because body-repair may not be limited to muscle-damage alone.
- Maybe one day, technologies like this can be used to make us even better, not just repair damage, like Dr. Abraham Erskine’s Super-Soldier Serum from the “Captain America” movie.
Read on to find out the details…
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Say What You Want, But The Weird Preoccupation With Blood Really Panned-Out:
So one of the original experimenters in the field was crazy old Elizabeth Bathory who thought the secret to youth and beauty was in the blood of young girls.
Though her methods were a lot more medieval than the guys at Ambrosia, she was still onto something if only intuitively.
Since then, more experiments on the subject started up back in the 1950s.
And more recently researchers have found all kinds of things, one example being a protein called GDF11.
The Solution Will Be A Cocktail With Both Adding & Subtracting:
But even those experimenters admitted it’s almost certainly a cocktail of many factors,
Because injections of just that protein didn’t produce effects as strong as when the test animals systems were joined through parabiosis.
If other ideas about substances like ferritin and the longevity of women are right,
There might also be things you’d want to filter or swap -out- of older blood too; like changing the oil in a car, which is one of the newer theories.
Young Blood Has So Many Benefits, It Just Has To Be Figured-Out:
Since the parabiosis work by McCay, Harvard, and Stanford all showed the young blood gave old mice:
1) Better joint cartilage
2) Improved brain activity
3) Increased exercise ability
4) Greater intelligence
and
5) Better memory
The recent work by UPMC that shows they found something else besides GDF11 supports the previous researchers’ idea that the effects probably have to come from a mix of factors.
And Fabrisia Ambrosio’s team found one more component while chasing down the subject of muscle repair.
The Weird Mail System Our Bodies Use To Send Messages All Around:
For some reason, yet another problem older people face is that their muscles don’t get repaired that well and tend to scar instead.
But why the difference if young people’s muscles heal up just fine?
You might want to check in with Moderna on their COVID-booster tech, because it turns out our bodies work in some really weird ways.
Fabrisia’s team looked very closely at these little information-shuttles traveling around the circulatory system called, “Extracellular Vesicles”.
The Pitt Team Finds The Actual Message That’s Being Sent:
These little containers act like envelopes that send messages of, you guessed it, the same type of genetic information Moderna uses to kill COVID; mRNA.
But these little envelopes go all around the circulatory system and check in with many things, including your muscles.
But the team didn’t stop there, they found out exactly what message is delivered and what the recipient does with it.
Getting A Really Special Message To The Exactly Right Spot:
In her team’s previous work, Fabrisia found a special regenerative compound that’s a protein just like GDF11 from before.
This protein is called Klotho because clearly UPMC are fans of the original “Total Recall” movie with Arnold Schwarzenegger.
And it does all kinds of anti-aging work including, you guessed it, -regenerating muscle!
Specifically, the way it does this is to turn on special muscle-specific stem-cells that make all the regeneration happen when the Klotho message gets to the right target.
Old Muscles Don’t Repair Because The Message System Loses Bandwidth:
The reason old muscles don’t repair as well is because older people and animals don’t have as many of the EV-message envelopes circulating around anymore,
And the ones they do have, just don’t have as many slots available for the regeneration message to get to the injury spot where it’s needed.
Just like the other young blood transfusion experiments, the PUMC team injected blood-plasma from young mice into the older ones,
Just Like Every Other Trial, Young Blood Transfusions Worked In This One Too:
And BOOM, muscle repair at injured cites started in-earnest again!
(they also verified the results by injecting serum with the EVs removed and showed there were no positive results without them)
So now, the team knows at least -some- of the messages they need to send to help people,
And also the specific envelope-vehicle they need to put them in so the body will do the right things with them.
Some Day, We Will All Look Like Steve Rogers. Even After 60!:
The next part of the job is to do a new test and make that happen similar to the way they’d do it with humans and get the desired results.
After that, maybe we can come back to the “Upgrade Everything” idea because it’s actually hard to gain muscle after a certain age, too.
The rebuilding-problem might also be the reason why; so perhaps everyone over 60 could look like Captain America or Yazemeenah Rossi.
All with just a little of Dr. Fabrisia’s super-soldier serum; Countess Elizabeth and Dr. Erskine would be proud!
PS: For the love of God, do not go out and try to drink it!
References & Links:
• Source(s): UPMC-EVs | UPMC-Regeneration
• Source Studies:
•NatureAging – Regulation of aged skeletal muscle regeneration by circulating extracellular vesicles
•NatureComm. – Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration
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