(and maybe Yours, too!)
A Nutritional Proverb:
Ok; The Chinese have an old saying: “Eat until you are seven-tenths full and save the other three-tenths for hunger.”
Now hold that idea, but Bruce-Lee your way over from one culture to the other & witness the brilliance that is Giovambattista Pani and his team at the Catholic University of the Sacred Heart in Rome.
Because the man, whose first name I cannot pronounce without spraining
something in [most of] my face, has chalked up YET ANOTHER win for our old pal, Calorie Restriction.
Calorie Restriction’s Many Benefits:
It’s long been suspected, and sporadically proved along the way, that some CR does the Body good; -and also the Mind.
Well the doc and his team have just discovered the specifics of it, and they involve a strange, complicated, & refluxing biochemical chain, all centering around a molecule called CREB1.
The Proverb’s Prescription Slows Aging of The Brain:
It turns out that if the mice in the study had their Daily Calorie Allowance Restricted to 70% of standard (just as recommended by our old friends, the Chinese), they started expressing CREB1, which acts in the aforementioned chain with a Sirtuin-class Enzyme: Sirt-1, and DNA.
And that Mad, Wild, Rachel-Brice-Weapons-Grade, Dervishing-Waltz of reactions, and ‘-NAs, and ‘-ases, and ‘-EBs, and ‘-tuins, turns out to Slow Aging of The Brain.
Reduced Disease & Increased Mental Sharpness:
The restricted mice didn’t develop Obesity, Diabetes, Agression-problems, Alzheimer’s, or Parkinson’s. They retained & possibly Gained some greater cognitive performance.
And if they did get anything similar to Alzheimer’s, the symptoms were much less severe than the other mice; more on the order of a mild-dementia, for the same chronological age.
The Discovery of The Molecule Is Everything:
And here’s the great thing: Our Italian Pals Have Revealed [some of] THE WATCHWORKS!!!!!!!!!!!!!!
Before their Discovery, CR’s benefits to the brain at the molecular-level were more like Santeria or Voodoo.
-Let’s just Go*D*mn call him Gio’ okay?!! -GIO and his team Discovered and Displayed THE -ACTUAL, FREAKING- MOLECULE AT THE CENTER OF THE BENEFITS!!!!
… annnnd, how can they be sure, you wonder???
-There comes the darker side of the story…
The -Presence- of The Molecule Is Everything, Too:
Mice without CREB1 in their brains, but still Calorie-Restricted, experienced NONE OF THE BENEFITS.
[dun, dun, duuuuuuunnnnn!]
AND -HUMANS- CAN BE -JUST- AS CREB1-LESS AS A LAB MOUSE!
Can We Get CREB1 To Those Who Don’t Have It?:
So: Going forward, the idea is to somehow:
1) Isolate the compound and get it into the brains of humans who are deficient.
2) Create a drug/Campari-and-Soda-of-Drugs that contain the Molecules AND give the average person the benefit of the Reduction;
-Without the [actual] Reduction.
Calorie Restriction Is Hellish-Awesome:
(because, I can tell you, as somebody who has tried CR, unless you’re eating exclusively Spinach and Horsebread all day, with nary a drop of fat or 1 gram of Fast Carbs, CR is MURDEROUS on a normal person.
-and by “murderous”, I mean, “no more chocolate. zip. zero. zilch. nada. niente. naught. nnnnnnnnnnn….. [ok, I just made myself cry there for a sec…; hang on-…]”.)
So: there you are. Calorie Restriction. Proved. Once-Again. And this time for brains!
Drugs, Tomorrow; THEN ONWARD TO -VICTORY-!!!!!!
JUMP BONUS!, The Lovely Rachel Brice, videoed Live at Zulu Lounge:
Denzel Washington and Liev Schrieber, Publicity Still, “The Manchurian Candidate”, by Jonathan Demme, Scott Rudin Productions, Paramount Pictures
Bruce Lee, Publicity Still, “Enter The Dragon”, by Bruce Lee, Robert Clouse, Golden Harvest, Warner Brothers Pictures
Pinky and The Brain, Cartoon Series Publicity Artwork, by Tom Ruegger, Warner Brothers Animation, Amblin Entertainment
Rachel Brice at Zulu Lounge with Fishtank, by Richard Lowe, renaissancefaire.net
• via: Geekosystem
• More Coverage: UCSC,Rome-M&S Dept. | UCSC, Giovambattista Pani | Wikipedia-Way of The Dragon | HT-Keep Muscles Young, wi- oops; … ; … –I HAVE FALLEN AND I CAN’T GET UP!!! -or: Duck, Duck, UNABOMBER!
• Source Study: PNAS-A role for neuronal cAMP responsive-element binding (CREB)-1 in brain responses to calorie restriction